Positive Association Between Serum Level of Glyceraldehyde-Derived Advanced Glycation End Products and Vascular Inflammation Evaluated by [F]Fluorodeoxyglucose Positron Emission Tomography
نویسندگان
چکیده
RESEARCH DESIGNANDMETHODSdThe study involved 275 outpatients at Kurume University, Japan (189males and 86 females; mean age 61.26 8.8 years) who underwent complete history and physical examinations and determinations of blood chemistry and anthropometric variables, includingAGEs. SerumAGE levelwas examinedby enzyme-linked immunosorbent assay. Vascular [F]fluorodeoxyglucose (FDG) uptake, an index of vascular inflammation, was measured as blood-normalized standardized uptake value, known as the target-to-background ratio (TBR), by FDG–positron emission tomography (FDG-PET). Furthermore, we examined whether the changes in serum AGE level after treatment with oral hypoglycemia agents (OHAs) were correlated with those of TBR in another 18 subjects whose AGE value was.14.2 units/mL (mean 6 2 SD).
منابع مشابه
Positive Association Between Serum Level of Glyceraldehyde-Derived Advanced Glycation End Products and Vascular Inflammation Evaluated by [18F]Fluorodeoxyglucose Positron Emission Tomography
OBJECTIVE Advanced glycation end products (AGEs) evoke inflammatory reactions, contributing to the development and progression of atherosclerosis. We investigated the relationship between serum AGE level and vascular inflammation. RESEARCH DESIGN AND METHODS The study involved 275 outpatients at Kurume University, Japan (189 males and 86 females; mean age 61.2 ± 8.8 years) who underwent compl...
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